PRECLINICAL AND CLINICAL PHARMACOLOGY
Armando Genazzani (12 h, 2 ECTS)
He has authored over 150 papers in international journals and is a named inventor on four patents in the field that have been licenced or have been the object of research contracts with pharmaceutical companies. He has also received the David Phillips Fellowship for research in marine biology and the Marine Biology station of Plymouth in 1997 and the Galeno Prize for Young Scientists in 2008.
At present he organizes a Masters degree in Regulatory Affairs and Market Access, is the Vice-Rector of the University for International Relations and is on the expert panel of the World Health Organization for international non-proprietary names. He has sat on the Scientific-Technical Committee of the Italian Medicine’s Agency (AIFA) from 2015 to 2018 and at present sits on the Institutional Review Boards for Clinical Research.
Guest lecturers: 0
Laboratory: 0
Mariagrazia Grilli (6 h, 1 ECTS)
Guest lecturers: 0
Laboratory: 0
Fausto Chiazza (6 h, 1 ECTS)
the characterization of the molecular basis of metabolic diseases, mainly focusing on the investigation of inflammatory pathways and identification of mediators of inter-organ communication in these settings;
the study of the cellular mechanisms at the basis of the neurological complications of diabetes;
the pharmacological modulation of these pathways aimed at the prevention/management of the health consequences of metabolic related inflammation (“metaflammation”), as one of the key drivers of metabolic disorders and related neurological/cardiovascular co-morbidities.
Guest lecturers: 0
Laboratory: 0
Furthermore, the course will provide students with the ability to read and critically analyze pre-clinical and clinical data. Importantly, lectures and exercises will deal with the genral principles of pharmacology, and will include PK and binding exercises.
Title | Preclinical and clinical pharmacology |
Program
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Advanced principles of general pharmacology including robustness of data, risk/benefit profile and unmet therapeutic need.
Animal models in drug discovery:
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Textbooks |
Lecture notes; Scientific articles from the literature; Goodman and Gilman, The Pharmacological basis of therapeutics. |
Objectives |
The course aims to allow students to understand the general principles of drug action. Furthermore, it also to allow students to understand current standards and unmet therapeutic needs and to participate in preclinical and clinical drug developments. Single drugs and drug classes used in dermatology will be dealt with during the assignment. |
Pre-requisites |
Basic knowledge of pharmacology, including pharmacokinetics and pharmacodynamics.
|
Teaching methods | Traditional lectures, discussion of case studies, work groups. |
Expected Results |
At the end of the course, the student is expected to throughly know the principles governing drug action for both small chemical entities and biological drugs. He/she will also be expected to know the molecular mechanisms, the side effects and the potential and limits of the assigned drug as a platform to be able to disclose any other drug. Students are expected to critically analyse the translational value of animal models as well as to understand challenges and limitations of recapitulating human disorders in animal species for pharmacological studies. |
Exam modality |
The exam mark is composed of 3 parts:
|
Furthermore, the course will provide students with the ability to read and critically analyze pre-clinical and clinical data. Importantly, lectures and exercises will deal with the genral principles of pharmacology, and will include PK and binding exercises.
TITLE
Preclinical and clinical pharmacology
PROGRAM
Advanced principles of general pharmacology including robustness of data, risk/benefit profile and unmet therapeutic need.
- Principles of occupancy theory;
- Nomenclature of drugs;
- Benefit/risk;
- Pharmacokinetics;
- Binding calculations;
- Pharmacokinetic calculations.
Animal models in drug discovery:
- The European legislation on the use of animals in research
- Conventional and less conventional animal models
- The concepts of “validity” for animal models
- The use of genetically modified animals as relevant tools in drug discovery
- Discussion of selected animal models for relevant human disorders
- Animal models of skin diseases
TEXTBOOKS
Lecture notes;
Scientific articles from the literature;
Goodman and Gilman, The Pharmacological basis of therapeutics.
OBJECTIVES
The course aims to allow students to understand the general principles of drug action.
Furthermore, it also to allow students to understand current standards and unmet therapeutic needs and to participate in preclinical and clinical drug developments.
Single drugs and drug classes used in dermatology will be dealt with during the assignment.
PREREQUISITES
Basic knowledge of pharmacology, including pharmacokinetics and pharmacodynamics.
TEACHING METHODS
Traditional lectures, discussion of case studies, work groups.
EXPECTED RESULTS
At the end of the course, the student is expected to throughly know the principles governing drug action for both small chemical entities and biological drugs. He/she will also be expected to know the molecular mechanisms, the side effects and the potential and limits of the assigned drug as a platform to be able to disclose any other drug.
Students are expected to critically analyse the translational value of animal models as well as to understand challenges and limitations of recapitulating human disorders in animal species for pharmacological studies.
EXAM MODALITY
The exam mark is composed of 3 parts:
- A written part with 4 questions taken from the program. It would be expected that students are able to summarize the information given at lectures and to implement it from data from the literature. For the part on animal models, students will be required to give a power point presentation describing an animal model of their choice and critically dissect its advantages and limitations for drug discovery.
- A written exam in which students are expected to undertake binding and pharmacokinetic calculations in problems similar to those posted on the common repository;
Last modified: January 9, 2023