PRINCIPLES OF FORMULATION

Giovannelli (24 h –4 ECTS)

She received her degree in Pharmaceutical Chemistry and Technology at the University of Turin in 1998. Currently, she is Assistant Professor of Pharmaceutical Technology at the Department of Pharmaceutical Sciences (UPO). Her research interests focus on the preformulation of pharmaceutical and cosmetic molecules by interaction with excipients/technological adjuvants, formation of supra-molecular inclusion compounds with cyclodextrins and modification of the physical state by techniques such as freeze drying and spray drying.

Academic lecturers: 0

Guest lecturers: 24

Laboratory: 0

Title Principles of formulation (4 ECTS)
Program

 

Introduction: Dosage forms and administration routes. Biopharmaceutical considerations. Factors affecting the absorption of the drug substance from different administration routes. The concept of preformulation.

Guest lecturer – 6 hours

Liquid and dispersed systems: Types (solutions, colloids, suspensions, emulsions), properties, stability, excipients, pharmaceutical applications, requirements.

Guest lecturer – 6 hours

Semisolid preparations: Rational approach to drug delivery to and via the skin; physico-chemical and biological factors affecting drug penetration, percutaneous permeation and absorption. Principles of rheology, excipients. Dermatological formulations: gels, ointments, creams, pastes. Transdermal therapeutic systems.

Guest lecturer – 6 hours

Cosmetic formulations:

Skin care, hair care and sun care formulations; decorative products.

Guest lecturer – 6 hours

Textbooks The Design and Manufacture of Medicines; K. Aulton, Elsevier.

Handbook of Cosmetic Science and Technology; A. O. Barel et al.,  CRC Press.

Objectives The course aims to provide students with the basic principles of the formulation, illustrating in particular the physical-chemical characteristics of the excipients used for the preparation of dosage forms for topical application. An overview of skin care, sun care and decorative products will also be presented.
Prerequisites Basic knowledge of chemistry, human anatomy and physiology of skin; fundamentals of medicinal chemistry and pharmacology.
Teaching methods Lectures and seminars held by experts in the field.
Expected Results At the end of the course, the students should know the main technological features of the excipients used in topical forms, both dermatological and cosmetic. Some of the principles and techniques learnt during the course will be put in practice during the laboratory experiences of the course “Strategies for the synthesis, extraction of novel compounds, formulation and analysis of dermatological products” (at the end of the 2nd semester).
Exam modality Written test. Multiple choice, true/false type questions are the most frequent types of questions. 1 point for the correct answer, 0 points for wrong or blank answers.  20 questions for each 5-hour block. Each exam will cover the topics delivered in lectures.

TITLE

Principles of formulation (4 ECTS)

PROGRAM

Introduction: Dosage forms and administration routes. Biopharmaceutical considerations. Factors affecting the absorption of the drug substance from different administration routes. The concept of preformulation.

Guest lecturer – 6 hours

Liquid and dispersed systems: Types (solutions, colloids, suspensions, emulsions), properties, stability, excipients, pharmaceutical applications, requirements.

Guest lecturer – 6 hours

Semisolid preparations: Rational approach to drug delivery to and via the skin; physico-chemical and biological factors affecting drug penetration, percutaneous permeation and absorption. Principles of rheology, excipients. Dermatological formulations: gels, ointments, creams, pastes. Transdermal therapeutic systems.

Guest lecturer – 6 hours

Cosmetic formulations:

Skin care, hair care and sun care formulations; decorative products.

Guest lecturer – 6 hours

TEXTBOOKS

The Design and Manufacture of Medicines; K. Aulton, Elsevier.

Handbook of Cosmetic Science and Technology; A. O. Barel et al.,  CRC Press

OBJECTIVES

The course aims to provide students with the basic principles of the formulation, illustrating in particular the physical-chemical characteristics of the excipients used for the preparation of dosage forms for topical application. An overview of skin care, sun care and decorative products will also be presented.

PREREQUISITES

Basic knowledge of chemistry, human anatomy and physiology of skin; fundamentals of medicinal chemistry and pharmacology.

TEACHING METHODS

Lectures and seminars held by experts in the field.

EXPECTED RESULTS

At the end of the course, the students should know the main technological features of the excipients used in topical forms, both dermatological and cosmetic. Some of the principles and techniques learnt during the course will be put in practice during the laboratory experiences of the course “Strategies for the synthesis, extraction of novel compounds, formulation and analysis of dermatological products” (at the end of the 2nd semester).

EXAM MODALITY

Written test. Multiple choice, true/false type questions are the most frequent types of questions. 1 point for the correct answer, 0 points for wrong or blank answers.  20 questions for each 5-hour block. Each exam will cover the topics delivered in lectures.

Last modified: May 04, 2020