PRECLINICAL AND CLINICAL PHARMACOLOGY

Armando Genazzani
Armando Genazzani obtained his degree in Medicine and Surgery in 1992. He then moved to Oxford, to the Eidgenössische Technische Hochschule (ETH, Zurich; where he held an EMBO long-term fellowship) and to Cambridge, where he was appointed to a lectureship up to retirement age and was also named an Official Fellow and graduate tutor of Clare Hall.He returned to Italy in 2003 and is now a Full Professor of Pharmacology.

He has authored over 150 papers in international journals and is a named inventor on four patents in the field that have been licenced or have been the object of research contracts with pharmaceutical companies. He has also received the David Phillips Fellowship for research in marine biology and the Marine Biology station of Plymouth in 1997 and the Galeno Prize for Young Scientists in 2008.

At present he organizes a Masters degree in Regulatory Affairs and Market Access, is the Vice-Rector of the University for International Relations and is on the expert panel of the World Health Organization for international non-proprietary names. He has sat on the Scientific-Technical Committee of the Italian Medicine’s Agency (AIFA) from 2015 to 2018 and at present sits on the Institutional Review Boards for Clinical Research.

Academic lecturers: 12

Guest lecturers: 12

Laboratory: 0

Title Preclinical and clinical pharmacology
Program

 

Advanced principles of general pharmacology including robustness of data, risk/benefit profile and unmet therapeutic need.

–        Glucocorticoids;

–        Retinoids;

–        Vitamin analogues;

–        Photochemotherapy;

–        Anti-histamine agents;

–        Main classes of antibiotics, antifungals, and antiviral agents of dermatological interest;

–        Treatment of infestations;

–        Cytotoxic and immunosuppressive agents;

–        Biological drugs (e.g. for psoriasis, arthritic psoriasis, urticaria);

–        Immunoglobulins;

–        Treatment of skin cancers;

–        Other drugs (alopecia, hyperpigmentation, hypercheratosis, etc, pruritus, pain)

Textbooks Lecture notes;

Scientific articles from the literature;

Goodman and Gilman, The Pharmacological basis of therapeutics.

Objectives The course aims to allow students to understand the general principles pof drug action. Furthermore, it also aims t ogive a comprehensive view of the drugs used in dermatology, to aloe students to understand current standards and unmet therapeutic needs.
Pre-requisites Basic knowledge of pharmacology, including pharmacokinetics and pharmacodynamics.

 

Teaching methods Traditional lectures.
Expected Results At the end of the course, the student is expected to thoroughly know the principles governing drug action for both small chemical entitities and biological drugs. He(she will also be expected to know the molecular mechanisms, the side effects and the potential and limits of the main classes of drugs acting on skin.

 

Exam modality The exam mark will be composed of a single part: 3 questions taken from the program. It would be expected that students are able to summarize the information given at lectures and to implement it from data from the literature.

TITLE

Preclinical and clinical pharmacology

PROGRAM

Advanced principles of general pharmacology including robustness of data, risk/benefit profile and unmet therapeutic need.

  • Glucocorticoids;
  • Retinoids;
  • Vitamin analogues;
  • Photochemotherapy;
  • Anti-histamine agents;
  • Main classes of antibiotics, antifungals, and antiviral agents of dermatological interest;
  • Treatment of infestations;
  • Cytotoxic and immunosuppressive agents;
  • Biological drugs (e.g. for psoriasis, arthritic psoriasis, urticaria);
  • Immunoglobulins;
  • Treatment of skin cancers;

Other drugs (alopecia, hyperpigmentation, hypercheratosis, etc, pruritus, pain)

TEXTBOOKS

Lecture notes;

Scientific articles from the literature;

Goodman and Gilman, The Pharmacological basis of therapeutics.

OBJECTIVES

The course aims to allow students to understand the general principles pof drug action. Furthermore, it also aims t ogive a comprehensive view of the drugs used in dermatology, to aloe students to understand current standards and unmet therapeutic needs.

PREREQUISITES

Basic knowledge of pharmacology, including pharmacokinetics and pharmacodynamics.

TEACHING METHODS

Traditional lectures.

EXPECTED RESULTS

At the end of the course, the student is expected to thoroughly know the principles governing drug action for both small chemical entitities and biological drugs. He(she will also be expected to know the molecular mechanisms, the side effects and the potential and limits of the main classes of drugs acting on skin.

EXAM MODALITY

The exam mark will be composed of a single part: 3 questions taken from the program. It would be expected that students are able to summarize the information given at lectures and to implement it from data from the literature.

Last modified: March 31, 2020