ORGANIC CHEMISTRY

Alberto Minassi (24 h – 4 ECTS)

He obtained his PhD in Science of Bioactive Compounds in 2004 and he was a visiting scientist at Endocannabinoid Research Group – CNR – Pozzuoli (Italy) and at the laboratory of Prof. Clayden – University of Manchester (UK). He is currently Associate Professor of Organic Chemistry at the Department of Pharmaceutical Sciences (UPO). His research interests include the chemistry of natural products and the development of novel synthetic methodologies in the synthesis of natural compounds.

Academic lecturers: 24

Guest lecturers: 0

Laboratory: 0

Title Organic Chemistry (4 ECTS)
Program ·       Reactivity of the main functional groups in organic chemistry (alkane, alkene, alkyne, alcohol, aldehyde, ketone, carboxylic acid, amide, ester)

·       Reactivity of aromatic and heterocyclic compounds

·       Summary exercises

Minassi A. – 24 hours (frontal lessons)

Textbooks William H. Brown, Brent L. Iverson, Eric V. Anslyn, Christopher S. Foote, Bruce M. Novak Organic Chemistry;

John McMurry Organic Chemistry

The slides of the lectures and additional material will be available to students.

Objectives The aim of this organic chemistry course is to introduce students to many of the key concepts of organic chemistry through a survey of the basic reactions of selected mono and polyfunctional aliphatic and aromatic molecules. Particular emphasis is placed on the underlying mechanistic pathways that are involved, together with some of their stereochemical consequences.
Prerequisites Basic knowledge of general and organic chemistry is mandatory and can be acquired by pre-course intensive tutoring that will cover:

Basic principles of general chemistry

Basic principles of organic chemistry:

·       Isomerism

·       Resonance and its application (drawing resonance structures)

·       Electronic properties of the main functional groups

·       Stereochemistry

·       Fondamentals of general, organic and biological chemistry; McMurry; Pearson

Teaching methods Lectures and exercises.
Expected Results Students should be able:

·       to predict the reactivity of an organic compound from its structure

·       to propose a multi-step synthesis of organic compounds

·       to apply the key concepts of organic chemistry in synthetic processes of molecules of pharmaceutical importance

Exam modality The exam mark will be composed of two parts:

The first part will be composed by 7 synthetic sequences where it is required to draw the correct product of each reaction. Every sequence is equivalent to a score of 3 points for a total amount of 21 points.

The second part will be a powerpoint presentation where the students, divided in 3 groups, have to compare the synthetic strategies used for the synthesis of a drug, assigned by the lecturer, both by the originator and by the competitors. This will be an open discussion session, and it is worth 7 points.

TITLE

Organic Chemistry (4 ECTS)

 

PROGRAM

  • Reactivity of the main functional groups in organic chemistry (alkane, alkene, alkyne, alcohol, aldehyde, ketone, carboxylic acid, amide, ester)
  • Reactivity of aromatic and heterocyclic compounds
  • Summary exercises

Minassi A. – 24 hours (frontal lessons)

TEXTBOOKS

William H. Brown, Brent L. Iverson, Eric V. Anslyn, Christopher S. Foote, Bruce M. Novak Organic Chemistry;

John McMurry Organic Chemistry

The slides of the lectures and additional material will be available to students.

OBJECTIVES

The aim of this organic chemistry course is to introduce students to many of the key concepts of organic chemistry through a survey of the basic reactions of selected mono and polyfunctional aliphatic and aromatic molecules. Particular emphasis is placed on the underlying mechanistic pathways that are involved, together with some of their stereochemical consequences.

PREREQUISITES

Basic knowledge of general and organic chemistry is mandatory and can be acquired by pre-course intensive tutoring that will cover:

Basic principles of general chemistry

Basic principles of organic chemistry:

  • Isomerism
  • Resonance and its application (drawing resonance structures)
  • Electronic properties of the main functional groups

Stereochemistry

Fondamentals of general, organic and biological chemistry; McMurry; Pearson

TEACHING METHODS

Lectures and exercises.

EXPECTED RESULTS

Students should be able:

  • to predict the reactivity of an organic compound from its structure
  • to propose a multi-step synthesis of organic compounds

to apply the key concepts of organic chemistry in synthetic processes of molecules of pharmaceutical importance

EXAM MODALITY

The exam mark will be composed of two parts:

The first part will be composed by 7 synthetic sequences where it is required to draw the correct product of each reaction. Every sequence is equivalent to a score of 3 points for a total amount of 21 points.

The second part will be a powerpoint presentation where the students, divided in 3 groups, have to compare the synthetic strategies used for the synthesis of a drug, assigned by the lecturer, both by the originator and by the competitors. This will be an open discussion session, and it is worth 7 points.

Last modified: November 06, 2019