COSMETIC AND DERMATOLOGICAL PRODUCTS ON THE MARKET: FROM MOLECULAR BIOLOGY TO MARKET

Asia Fernandez-Carvajal, Antonio Ferrer-Montiel, Guest Lecturers (24 h - 3 ECTS)

Asia Fernández-Carvajal obtained her degree in Biochemistry in 1992. She has authored about 55 papers in international journals. At present, she is an Associate Professor of Biochemistry and Molecular Biology, the Director of the Master on Biotechnology and Bioengineering and participates in the PhD Program on Molecular and Cellular Biology of the IBMC.  She has a proven track record in the evaluation of different aspects of the planning of screening and validation of targets, in drug discovery, in the design and automation of testing and in the use of software required for the stored and automated analysis of data. She has registered 10 patents of new compounds, analgesics and cosmetics. She is founder of Antalgenics SL., a Spin-off biotechnological company focused on the development of novel molecules for topical treatment of skin pathologies by modulating the neurosensory system.

Antonio Ferrer-Montiel obtained his degree in Chemistry in 1989. At present he is a Full Professor of Biochemistry and Molecular Biology Department and participates in the Master on Biotechnology and Bioengineering and in the PhD Program on Molecular and Cellular Biology of the IBMC. He is an expert on ion channels and, particularly, on TRP channels. He has authored about 125 papers in international journals and is a named inventor on 29 patents of new compounds analgesics and cosmetics. The investigations carried out in the last 15 years for cosmetic companies has resulted in the marketing of 15 products. He has contracts and agreements of collaboration with companies for the evaluation of the efficacy, quality, safety and development of cosmetics (Labiofam, Diverdrugs, SL, BCN Peptides, Lipotec, S.A, GP Pharm SA, ASAC Pharma SA). He is scientific advisor of several enterprises: Lipotec, BCN Peptides, GP Pharm, BioArray SL, Prima-Derm and Angelini.  He is Executive President and Founder of Prospera Biotech SL, Antalgenics SL, Fastbase Solutions SL. He has been Founder Member and Chief Scientific Officer of Diverdrugs until it was sold to Lubrizol corporation.

Theory: 12 h

Laboratory: 12 h

Title Cosmetic and dermatological products on the market: from molecular biology to market (3 ECTS)
Program

 

 1.   Introduction: science in dermocosmetics (2 hours)

2.   Dermocosmetics development (2 hours)

a.      Target identification.

b.     High performance functional tests and their limitations.

c.      Biotechnology-derived ingredients: peptides, proteins and growth factors

d.     Stem-cell-based products

3.   Advanced Technologies in Dermatological Products (2 hours)

a.      Delivery

b.     Nanoparticles

c.      Nanofibers

4.   Market penetration, merchandising, market orientations (2 hours)

5.   Value development: pricing strategies (2 hours)

 
Sources –      Basic Science for Modern Cosmetic Dermatology. Jaypee Brothers Medical Publishers; UK ed. Edition. 2015

–       Lead generation approaches in drug discovery. Zora Rankovic. Wiley 2010.

–      Prodrugs and targeted delivery. Towards better ADME properties. Jarkko Rautio. Wiley. 2011.

–      Cosmeceuticals. Zoe Diana Draelos, Jeffrey S Dover and Murad Alam. Procedures in Cosmetic Dermatology. Elsevier Saunders. 2005.

–      Selected scientific papers published by top ranking journals on the topic (e.g. Journal of Investigative Dermatology, International journal of cosmetic science.
Objectives and expected results 1.     Acquire knowledge about:

1.1.  the bases and foundations of the different high performance functional tests.

1.2.  the design, tracking and deconvolution of natural and synthetic combinatorial libraries.

2.     Recognize and validate bioactive compounds as hits for pharmaceutical, cosmetic and nutricosmetic development.

3.     Know the standards for the development of active compounds in cosmeceuticals and nutraceuticals.

4.     Recognize the patentability of scientific results / knowledge.

5.     Understand the strategy of repositioning medications and bioactive molecules.
Prerequisites Pharmacology, pharmacokinetics, pharmacodynamics.
Teaching methods Theoretical sessions will be based on classic lectures, but using interactive technologies and apps. Discussion between lecturers and students and journal club discussions will be also used to reinforce the main topics.

 

Practical sessions will be based on team and individual tasks. During these practical sessions, student will be asked to use internet resources and scientific databases to develop their exercises.

 
Exam modality 40% of the mark. A final written exam evaluating the knowledge and notions acquired during the lectures and practical sessions; the test will consist of up to 4 open questions (answers of 100-150 words maximum) and 30-40 multiple choice questions (with one true answer).

30% of the mark. After each practical session, student will prepare the required documentation that will be graded according the given instructions.

30% of the mark: a written assay that will cover the project that will be assigned by the lecturer

TITLE

Cosmetic and dermatological products on the market: from molecular biology to market (3 ECTS)

 

PROGRAM

  1. Introduction: science in dermocosmetics (2 hours)
  2. Dermocosmetics development (2 hours)
    1. Target identification.
    2. High performance functional tests and their limitations.
    3. Biotechnology-derived ingredients: peptides, proteins and growth factors
    4. Stem-cell-based products
  3. Advanced Technologies in Dermatological Products (2 hours)
    1. Delivery
    2. Nanoparticles
    3. Nanofibers
  4. Market penetration, merchandising, market orientations (2 hours)
  5. Value development: pricing strategies (2 hours)

SOURCES

  • Basic Science for Modern Cosmetic Dermatology. Jaypee Brothers Medical Publishers; UK ed. 2015
  • Lead generation approaches in drug discovery. Zora Rankovic. Wiley 2010.
  • Prodrugs and targeted delivery. Towards better ADME properties. Jarkko Rautio. Wiley. 2011.
  • Zoe Diana Draelos, Jeffrey S Dover and Murad Alam. Procedures in Cosmetic Dermatology. Elsevier Saunders. 2005.
  • Selected scientific papers published by top ranking journals on the topic (e.g. Journal of Investigative Dermatology, International journal of cosmetic science.

OBJECTIVES AND EXPECTED RESULTS

  1. Acquire knowledge about:
    • the bases and foundations of the different high performance functional tests.
    • the design, tracking and deconvolution of natural and synthetic combinatorial libraries.
  2. Recognize and validate bioactive compounds as hits for pharmaceutical, cosmetic and nutricosmetic development.
  3. Know the standards for the development of active compounds in cosmeceuticals and nutraceuticals.
  4. Recognize the patentability of scientific results / knowledge.
  5. Understand the strategy of repositioning medications and bioactive molecules.

PREREQUISITES

Pharmacology, pharmacokinetics, pharmacodynamics.

TEACHING METHODS

Theoretical sessions will be based on classic lectures, but using interactive technologies and apps. Discussion between lecturers and students and journal club discussions will be also used to reinforce the main topics.

Practical sessions will be based on team and individual tasks. During these practical sessions, student will be asked to use internet resources and scientific databases to develop their exercises.

EXAM MODALITY

40% of the mark. A final written exam evaluating the knowledge and notions acquired during the lectures and practical sessions; the test will consist of up to 4 open questions (answers of 100-150 words maximum) and 30-40 multiple choice questions (with one true answer).

30% of the mark. After each practical session, student will prepare the required documentation that will be graded according the given instructions.

30% of the mark: a written assay that will cover the project that will be assigned by the lecturer

Last modified: January 07, 2020

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